Terpenes: The Entourage Effect

The importance of terpenes in all species of plants, especially cannabis, can’t be underestimated. Terpenes are fundamental building blocks of the cannabis plant and have a very important and influential role to play in the plant’s overall biological makeup and all compounds that are derived from it.

What Exactly are Terpenes in Plant Science?

Terpenes are essential building blocks of many different plant varieties and are essentially what gives each plant their special aroma and flavor. Technically, terpenes are groupings of hydrocarbons that give plants their specific flavors and aromas.

Lemons are a fantastic example of illustrating the power of terpenes in a relatable way. Without terpenes, a lemon would not have the flavor and scent profile that we all associate with the lemon. It’s the terpene called Limonene that is responsible for that special flavor and aroma. Limonene is also a terpene that is present in cannabis.

Pinene is another example of a common terpene that is also present in cannabis. Pinene gives off an earthy smell that is very specific to many coniferous trees and bushes all around the world. When describing the scent and aroma of pine, some say the aroma is similar to vanilla. Others say that there are hints of butterscotch. In addition to its powerful scent and aromas, it produces many beneficial effects in the context of cannabis which we will cover below.

Common Terpenes In Cannabis & Their Aromas and Effects

Depending upon the strain of cannabis, there can be vast amounts of terpenes present. Each one is different and lends itself to a scent or flavor. And each one has different reported characteristics and benefits.

While there is a myriad of terpenes present in the cannabis sativa plant, more than 120 at current count, there are a few we should look at more closely, as they are showing extremely beneficial results for medical marijuana users.

Here are some of the notable terpenes found in cannabis:


Commonly found in the resin of coniferous trees like the pine tree, α-pinene (“Pinene”), a primary isomer, can be found in cannabis, sage, eucalyptus, olive, rosemary, sassafras, and bergamot, to name a few. β-pinene, a secondary isomer, is found in hops and cumin. Pinene is a very prevalent terpene and has been harvested for centuries, used in alternative and holistic healing.

Pinene’s benefits are numerous. It offers antioxidant, antibacterial, antibiotic, and anti-inflammatory properties. Pinene is also increasingly studied and recognized in the medical community for its ability to aid in the slowing of cancer cell growth. In addition, Pinene is also known for its expectorant and Broncho dilative properties, helping those with respiratory issues.

When present in the cannabis plant, Pinene is known to counteract the psychoactive effects of THC, helpful to those who prefer to stay grounded while undergoing its effects.


This is a spicy, often floral scent, found in many plants including mint, rosewood, lavender, and cinnamon. It has sedative and calming effects, used as a sleep aid for centuries.

Linalool is known for its anti-depressant, anxiolytic, and anti-inflammatory properties. It offers pain relief and is studied for its ability to inhibit cancer cell growth and regeneration.


Found in clove, basil, coriander, and hops (cannabis’s cousin), Humulene gives off an earthy, woody, and spicy aroma.

Humulene has been used in holistic healing for thousands of years because it possesses powerful anti-inflammatory and antibacterial properties and can be utilized as a pain reliever and tonic.


Found in apple, tea tree, cumin, some citrus fruits, oregano, and marjoram, this smoky and woody terpene is also common to the cannabis plant.

It is known for its sedative effects, as well as anti-bacterial, anti-fungal, and antioxidant properties.


Limonene, which we’re already familiar with, is one of the most common and well-known terpenes. Found in citrus rinds, juniper, and peppermint, Limonene can be found in numerous foods, fragrances, and household cleaners. Limonene is known for its strong citrus aroma.

Limonene possesses a wide array of benefits, including its overall beneficial effects on the entire gastrointestinal system. Limonene also has antidepressant, anxiolytic, anti-fungal, and anti-inflammatory properties. In addition to all that, it is also sometimes used as an anti-proliferative and immune-stimulant, helping to protect from the carcinogens found in smoke. Limonene also helps with mental focus, concentration, and clarity.

Terpenes & The Entourage Effect

Entourage Effect is a scientific way of describing the interactions between cannbionoids and terpenoids.  When combined together the cannabinoids and terpenoids generate interactive synergy.  The study of terpenoids in relation to cannabinoids is uncovering new findings as it pertains to the effectiveness of “whole plant medicine,” a term used to explain how cannabinoids and terpenes work together to provide symptomatic relief across a wide range of medical conditions and symptoms.

Although the benefits of terpenes are impressive in isolation, the Entourage Effect displays how, when combined with other terpenes or synergized with cannabinoids such as THC and CBD, that there is a definitive increase in beneficial properties, which means that the medicinal value of the cannabis plant drastically rises when the Entourage Effect comes into play.

When terpenes work together in harness harmony with cannabinoids, medicinal properties seem to augment their effectiveness, making the cannabis plant a true healer.

Research and Findings on The Entourage Effect

In 2010, Dr. Ethan Russo, a prominent neurologist, published his findings in the British Journal of Pharmacology. Dr. Russo studied the far-reaching effects of combining various compounds to produce the Entourage Effect. Different combinations include;

  • Individual– Allowing the terpene to product effects on its own. For instance, the terpene Myrcene helps to better allow chemical absorption by reducing resistance in the blood/brain barrier;
  • Combined with Other Terpenes- Using a combination of terpenes that produce similar effects to increase effectiveness. For example, some combine Pinene, Myrcene, and Caryophyllene with the belief that this combination effectively combats stress;
  • Combined with Other Cannabinoids- Directly combining terpenes with other partners of the cannabis plant such as CBD or CBD can create desired effects. For instance, combining the cannabinoid CBG with Linalool and Limonene may be an effective treatment against resistant staph infections such as MRSA

The Benefits of the Entourage Effect and a Call for Additional Research

Whole plant therapy is an increasingly more important category in medicine today. As science continues to study and reveal the benefits of the Entourage Effect and how cannabinoids exist on and perform at a molecular level, we are better able to learn how it affects the endocannabinoid system, both directly and indirectly.

Medically accessing the benefits of the Entourage Effect could greatly augment the positive and far-reaching potential that terpenes found in cannabis have on the body when they interact with other cannabinoids.

In short, terpenes are important. They have also been used for thousands of years in traditional remedies and herb-based medicines and now, thanks to technology and further research, we can finally understand the therapeutic benefits of terpenes so that they can take their rightful therapeutic place in science, health, and wellness.

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